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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ABCB1
All Species:
17.58
Human Site:
T747
Identified Species:
32.22
UniProt:
P08183
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P08183
NP_000918.2
1280
141479
T747
T
R
I
D
D
P
E
T
K
R
Q
N
S
N
L
Chimpanzee
Pan troglodytes
XP_519183
1280
141455
T747
T
R
I
D
D
P
E
T
K
R
Q
N
S
N
L
Rhesus Macaque
Macaca mulatta
NP_001028059
1283
141504
T750
T
R
N
D
D
A
E
T
K
R
Q
N
S
N
L
Dog
Lupus familis
XP_539461
1269
140189
T739
F
E
N
D
D
K
T
T
L
K
H
D
A
E
M
Cat
Felis silvestris
Mouse
Mus musculus
P21447
1276
140628
T743
T
N
G
G
P
P
E
T
Q
R
Q
N
S
N
L
Rat
Rattus norvegicus
P43245
1277
141369
T745
S
R
D
D
D
H
E
T
K
Q
R
N
C
N
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508941
1368
147746
V835
F
G
P
G
D
E
A
V
K
R
Q
K
C
D
M
Chicken
Gallus gallus
XP_418636
1307
144961
A774
F
V
E
K
G
K
A
A
I
R
E
T
N
S
T
Frog
Xenopus laevis
NP_001081394
1287
141487
Q755
V
F
A
G
P
V
S
Q
M
R
S
E
S
S
M
Zebra Danio
Brachydanio rerio
XP_001922717
1340
147081
V809
F
A
E
P
D
P
E
V
K
R
Q
K
T
M
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q00748
1302
143766
D767
L
A
E
K
D
P
E
D
A
L
R
R
T
A
V
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P34712
1321
145045
D788
V
F
A
G
N
P
A
D
F
L
S
Q
G
H
F
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O80725
1286
139009
K754
A
F
F
Q
P
P
K
K
L
K
E
D
T
S
F
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
96
55.7
N.A.
87.1
80.6
N.A.
62.1
69.6
67.6
56
N.A.
41.1
N.A.
44.5
N.A.
Protein Similarity:
100
99.8
97.7
75.4
N.A.
93.3
90.1
N.A.
76.6
83.6
81.8
73.5
N.A.
60.4
N.A.
62.6
N.A.
P-Site Identity:
100
100
86.6
20
N.A.
66.6
60
N.A.
26.6
6.6
13.3
40
N.A.
20
N.A.
6.6
N.A.
P-Site Similarity:
100
100
86.6
46.6
N.A.
73.3
80
N.A.
40
26.6
26.6
53.3
N.A.
40
N.A.
20
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
41.2
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
62.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
46.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
16
16
0
0
8
24
8
8
0
0
0
8
8
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
16
0
0
% C
% Asp:
0
0
8
39
62
0
0
16
0
0
0
16
0
8
0
% D
% Glu:
0
8
24
0
0
8
54
0
0
0
16
8
0
8
0
% E
% Phe:
31
24
8
0
0
0
0
0
8
0
0
0
0
0
16
% F
% Gly:
0
8
8
31
8
0
0
0
0
0
0
0
8
0
0
% G
% His:
0
0
0
0
0
8
0
0
0
0
8
0
0
8
0
% H
% Ile:
0
0
16
0
0
0
0
0
8
0
0
0
0
0
0
% I
% Lys:
0
0
0
16
0
16
8
8
47
16
0
16
0
0
0
% K
% Leu:
8
0
0
0
0
0
0
0
16
16
0
0
0
0
39
% L
% Met:
0
0
0
0
0
0
0
0
8
0
0
0
0
8
31
% M
% Asn:
0
8
16
0
8
0
0
0
0
0
0
39
8
39
0
% N
% Pro:
0
0
8
8
24
54
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
8
0
0
0
8
8
8
47
8
0
0
0
% Q
% Arg:
0
31
0
0
0
0
0
0
0
62
16
8
0
0
0
% R
% Ser:
8
0
0
0
0
0
8
0
0
0
16
0
39
24
0
% S
% Thr:
31
0
0
0
0
0
8
47
0
0
0
8
24
0
8
% T
% Val:
16
8
0
0
0
8
0
16
0
0
0
0
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _